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Changwei Shao


Changwei (Kevin) Shao Ph.D.

Associate Professor in Yellow Sea Fisheries Research Institute, CAFS

Nanjing Road 106, Qingdao, China

Office: +86-0532-85831605



Dr. Shao received his M.S. on marine biology in Ocean University of China in 2007 and then he worked on fish genomic analysis in Texas A&M University as a visiting scholar in 2008. In 2012, Dr. Shao received his Ph.D. on marine biology in Ocean University of China. Since 2012 to 2015, he worked Tokyo University of Marine Science and Technology as a JSPS fellow for three months per year and received another Ph.D. on marine science. He is now associate professor in the Yellow Sea Fisheries Research Institute, CAFS. Dr. Shao’s research focused on fish genome sequence, genome resource development, and molecular breeding as well as fundamental issues in fish evolutionary biology.He has more than 60 publications including the top journals such as Nature Genetics, Genome Research et al.

Research Interests:

The research focus is to use genomics and genetics to understand the basic biology in fish and to apply this information to improve the productivity and sustainability of economically important fish. Specific areas of interest include: (1) fish genome sequence and analysis of gene function and regulation as well as conserved non-coding regions (CNCs) at multi-omics levels, (2) development of genomic resources and selective breeding programs and elucidation of the genetic basis underlying commercially important traits through QTL mapping, whole genome association study (GWAS) and genomic selection (GS), (3) identification of fish sex determination gene and towards new understanding of the genetic and epigenetic mechanism of sex determination gene as well as their evolutionary interconnections with sex chromosome evolution, and (4) analysis of adaptive microevolution to answer how many and what kind of genetic changes accompany phenotypic variation among fish populations.

Selected Publications:

1. Songlin Chen, Guojie Zhang, Changwei Shao et al. Whole-genome sequence of a flatfish provides insights into ZW sex chromosome evolution and adaptation to a benthic lifestyle. Nature Genetics, 2014, 46: 253-260.

2. Changwei Shao, Qiye Li, Songlin Chen et al. Epigenetic modification and inheritance in sexual reversal of fish. Genome Research, 2014, 24 (4), 604-615.

3. Changwei Shao, Yongchao Niu, Pasi Rastas, et al. Genome-wide SNP identification for the construction of a high-resolution genetic map of Japanese flounder (Paralichthys olivaceus): applications to QTL mapping ofVibrio anguillarumdisease resistance and comparative genomic analysis. DNA Research, 2015, 22(2):161-170

4. Changwei Shao, Geng Liu, Shanshan Liu, Changlin Liu, Songlin Chen. Characterization of the cyp19a1a gene from a BAC sequence in half-smooth tongue sole (Cynoglossus semilaevis) and analysis of its conservation among teleosts. Acta Oceanologica Sinica, 2013, 32(8): 35-43.

5. Changwei Shao, Songlin Chen, Chantel F Scheuring, Jianyong Xu, Zhenxia Sha, Xiaoli Dong, Hongbin Zhang.Construction of two BAC libraries from half-smooth tongue sole Cynoglossussemilaevis and identification of clones containing candidate sex-determination genes. Marine Biotechnology, 2010, 12 (5): 558-568.

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