
杜康,男,1990年11月生人,于2018年6月获中国科学院水生生物研究所水生生物学专业的博士学位;2018年至2024年间先后于德国维尔茨堡大学、美国德克萨斯州立大学大学从事博士后研究工作;现任中国水产科学研究院黄海水产研究所研究员、硕士生导师、博士后合作导师;研究方向为:鱼类性别决定的遗传基础和演化机制。
主持国家自然科学基金优秀青年科学基金项目(海外);以第一作者(含并列)、共同通讯作者在Nature、Nature Ecology & Evolution、Nature Communications、Genome Research等杂志上发表多篇论文。
联系电话:0532-85831605
通讯地址:山东省青岛市南京路106号中国水产科学研究院黄海水产研究所
邮政编码:266071
E-mail:dukang@ysfri.ac.cn
微信:UFOalone
主要研究内容、研究方向
物竞天择,适者生存;然而,若无法繁衍,生存便失去了演化意义。有性生殖作为主要的繁衍方式,其起源十分古老,但各物种的性别决定机制却并不保守,展现出高度的可塑性和多样性,其背后的遗传机制和演化意义尚不得知。
本人以鱼类为研究模型,从系统发育学出发,调查性染色体的起源与演化模式;结合种群基因组学手段,追踪性别决定基因与性染色体的演变过程;同时引入单细胞测序与空间转录组等技术,探究性别决定系统的遗传机制和演化规律。
研究成果将有利于演化理论的推进和水产性控育种技术的发展。
代表性论著(*为共同一作,#为共同通讯)
1)Kang Du, Oliver Deusch, Ilja Bezrukov, Christa Lanz, Yann Guiguen, Margarete Hoffmann, Anette Habring, Detlef Weigel, Manfred Schartl & Christine Dreyer, “Identification of the male-specific region on the guppy Y Chromosome from a haplotype-resolved assembly.” Genome Research (2025)
2)Kang Du, Yuan Lu, Mateo Garcia-Olazabal, Ronald B Walter, Wesley C Warren, Tristram Dodge, Molly Schumer, Hyun Park, Axel Meyer & Manfred Schartl, “Phylogenomics analyses of all species of Swordtails (Genus Xiphophorus ) highlights hybridization precedes speciation.” Nature Communications (2024)
3)Min-Rui-Xuan Xu*, Zhen-Yang Liao*, Jordan R Brock*, Kang Du*, Guo-Yin Li, Zhi-Qiang Chen, Ying-Hao Wang, Zhong-Nan Gao, Gaurav Agarwal, Kevin H-C Wei, Feng Shao, Shuai Pang, Adrian E Platts, Jozefien van de Velde, Hong-Min Lin, Scott J Teresi, Kevin Bird, Chad E Niederhuth, Jin-Gen Xu, Guo-Hua Yu, Jian-Yuan Yang, Si-Fa Dai, Andrew Nelson, Ingo Braasch, Xiao-Gu Zhang, Manfred Schartl, Patrick P Edger, Min-Jin Han & Hua-Hao Zhang, “Maternal dominance contributes to subgenome differentiation in allopolyploid fishes.” Nature Communications (2023)
4)Heiner Kuhl*, Kang Du*, Manfred Schartl, Lukáš Kalous, Matthias Stöck & Dunja K. Lamatsch, “Equilibrated evolution of the mixed auto-/allopolyploid haplotype-resolved genome of the invasive hexaploid Prussian carp.” Nature Communications (2022)
5)Kang Du#, Martin Pippel, Susanne Kneitz, Romain Feron, Irene da Cruz, Sylke Winkler, Brigitta Wilde, Edgar G Avila Luna, Gene Myers, Yann Guiguen, Constantino Macias Garcia & Manfred Schartl#, “Genome biology of the Darkedged Splitfin, Girardinichthys multiradiatus, and the evolution of sex chromosomes and placentation.” Genome research (2022)
6)Axel Meyer*, Siegfried Schloissnig*, Paolo Franchini*, Kang Du*, Joost Woltering*, Iker Irisarri, Wai Yee Wong, Sergej Nowoshilow, Susanne Kneitz, Akane Kawaguchi, Andrej Fabrizius, Peiwen Xiong, Corentin Dechaud, Herman Spaink, Jean-Nicolas Volff, Oleg Simakov, Thorsten Burmester, Elly M. Tanaka & Manfred Schartl. “Giant lungfish genome elucidates the conquest of land by vertebrates.” Nature. (2021)
7)Kang Du, Matthias Stöck, Susanne Kneitz, Christophe Klopp, Joost Woltering, Mateus Adolfi, Romain Feron, Dmitry Prokopov, Alexey Makunin, Ilya Kichigin, Cornelia Schmidt, Petra Fischer, Heiner Kuhl, Sven Wuertz, Jörn Gessner, Werner Kloas, Cedric Cabau, Carole Iampietro, Hugues Parrinello, Chad Tomlinson, Laurent Journot, John Postlethwait, Ingo Braasch, Vladimir Trifonov, Wesley C Warren, Axel Meyer, Yann Guiguen & Manfred Schartl. “An ancient whole genome duplication in a living fossil: the sterlet sturgeon genome sequence and the mechanisms of segmental rediploidization.” Nature Ecology & Evolution (2020)